|
Analysis of Val158Met genotype polymorphisms in the COMT locus and correlation with IL-6 and IL-10 |
|
|
|
escrito por FJ Garcia-Fructuoso, K Beyer, JI Lao-Villadóniga ( Journal of clinicall research )
|
|
martes, 07 de marzo de 2006 |
|
http://www.pjbpubs.com/cms.asp?pageid=2212#1-10
Garcia-Fructuoso FJ, Beyer K, Lao-Villadóniga JI.
Analysis of Val158Met genotype polymorphisms in the COMT locus and correlation with IL-6 and IL-10 expression in fibromyalgia syndrome.
J Clin Res 2006; 9: 1-10
We have determined Val158Met COMT polymorphism genotypes (HH or Val/Val, HL or Val/Met, LL or Met/Met) in 46 fibromyalgia syndrome (FS) patients and 40 controls. A correlation between these alleles and Interleukin-6 (IL-6) and Interleukin-10 (IL-10) expression levels, determined by real-time RT-PCR, has been established. The accumulation of Met-allele carrying genotypes (both heterozygous and homozygous) observed in FS patients revealed an almost 4-fold increase of risk of developing FS. The Met(-) group of FM patients presented significantly increased IL-6 expression levels when compared to all other subgroups. Significantly lower IL-10 expression levels were observed in FS patients, especially in those FS cases carrying the Met allele in comparison with FS Met(-) patients and both control groups.
|
Inicio 
Sindrome Fatiga Cronica
Galería de Videos
