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MARCADORES DE ANTICUERPOS EXCEPCIONALMENTE BAJOS EN LA SINTESIS DE ELASTINA EN PACIENTES CON FM |
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escrito por web master
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lunes, 23 de octubre de 2006 |
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Abnormally Low Antibody Markers of Elastin Synthesis in Patients with Fibromyalgia Syndrome
Journal of Musculoskeletal Pain (ISSN: 1058-2452,)Volume: 14 Issue: 3, (2006), Page Range: 13 - 19
DOI: 10.1300/J094v14n03_03
Keith K. Colburn MD, John A. Rambharose MD, Marilyn C. Malto BS, Stephan Baydanoff PhD, Lawrence B. Sandberg MD, PhD, Lora M. Green PhD.
Keith K. Colburn MD, Chief of Rheumatology, Medical-111R & Research Service-151, Jerry L. Pettis Memorial Veteran Medical Center, Loma Linda, CA, 92350,
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John A. Rambharose MD, Department of Rheumatology, Loma Linda University School of Medicine, Loma Linda, CA, 92354 Marilyn C. Malto BS, Department of Rheumatology, Loma Linda University School of Medicine, Loma Linda, CA, 92354 Stephan Baydanoff PhD, Professor and Chairman, Department of Biology, Pleven, Pleven, Bulgaria Lawrence B. Sandberg MD, PhD, Professor, Microbiology & Biochemistry, Loma Linda University Graduate School, Loma Linda, CA, 92354 Lora M. Green PhD., Molecular Immunologist, Department of Rheumatology, Loma Linda University School of Medicine, Loma Linda, CA, 92354,
CONCLUSIONES: se detectaron variaciaciones en el metabolismo de la elastina en pacientes con Fibromialgia. Esta alteración en el metabolismo de la elastina ocurre en términos de una reducción de la producción de elastina en pacientes de fibromialgia. La relación entre el metabolismo de la elastina y la patologia de la enfermedad esta actualmente siendo investigada. |
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ELASTINA SEGUN WIKIPEDIA:
La elastina es una proteína estructural que forma parte de la matriz extracelular del tejido conjuntivo. En los mamíferos (en los vertebrados en general), se puede encontrar predominantemente allí donde el tejido sufre repetidos ciclos de extensión-relajación. Ejemplos típicos son las arterias, ligamentos, pulmones y piel. Presenta unas sorprendentes cualidades elásticas, quizá la más llamativa sea su alta resistencia a la fatiga. Las fibras elásticas de las arterias humanas (especialmente del arco aórtico) sobreviven más de 60 años, soportando miles de millones de ciclos de extensión-relajación. Aproximadamente el 90% de sus aminoácidos son de resto lateral apolar y existen ciertas secuencias que se encuentran repetidas como las VPG, VPGG, GVGVP, IPGVG, VAPGVG. La más común es la secuencia GVGVP, la cual aparece en fragmentos que contienen hasta 11 pentapéptidos consecutivos (VPGVG)11. enlaceAdvances in protein chemistry,2005, 70;437
Basados en las secuencias que se encuentran repetidas en la elastina natural se forman los polímeros tipo-elastina (ELP), de los cuales el de mayor renombre es el poly(VPGVG). Prog. Polym. Sci. 2005, 30 (11), 1119-1145
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ABSTRACT ORIGINAL:
Abnormally Low Antibody Markers of Elastin Synthesis in Patients with Fibromyalgia Syndrome
Journal of Musculoskeletal Pain (ISSN: 1058-2452,)Volume: 14 Issue: 3, (2006), Page Range: 13 - 19
DOI: 10.1300/J094v14n03_03
Keith K. Colburn MD, John A. Rambharose MD, Marilyn C. Malto BS, Stephan Baydanoff PhD, Lawrence B. Sandberg MD, PhD, Lora M. Green PhD.
Keith K. Colburn MD, Chief of Rheumatology, Medical-111R & Research Service-151, Jerry L. Pettis Memorial Veteran Medical Center, Loma Linda, CA, 92350,
Esta dirección de correo electrónico está protegida contra los robots de spam, necesita tener Javascript activado para poder verla
John A. Rambharose MD, Department of Rheumatology, Loma Linda University School of Medicine, Loma Linda, CA, 92354 Marilyn C. Malto BS, Department of Rheumatology, Loma Linda University School of Medicine, Loma Linda, CA, 92354 Stephan Baydanoff PhD, Professor and Chairman, Department of Biology, Pleven, Pleven, Bulgaria Lawrence B. Sandberg MD, PhD, Professor, Microbiology & Biochemistry, Loma Linda University Graduate School, Loma Linda, CA, 92354 Lora M. Green PhD., Molecular Immunologist, Department of Rheumatology, Loma Linda University School of Medicine, Loma Linda, CA, 92354,
Background: Antibodies [Abs] to tropoelastin [elastin precursor] and alpha-elastin [elastin breakdown product] are found in serum of all human subjects and correlate with their respective serum peptide levels; however, peptide levels vary with age and some disease states. This study was undertaken to determine if serum elastin Abs reflective of elastin metabolism were altered in patients with fibromyalgia syndrome [FMS] by determining the ratio of serum antitropoelastin to anti-alpha-elastin Ab levels.
Method: Serum samples from 20 female patients with FMS were compared with samples from 19 age-matched healthy normal control subjects for the levels of anti-elastin Abs directed against tropoelastin and alpha elastin using enzyme-linked immunosorbent assays.
Results: Anti-tropoelastin Abs in the sera of patients with FMS were decreased relative to the levels measured in healthy subjects [P < 0.0002].
The ratios of anti-tropoelastin to anti-alphaelastin Abs were 1.98 versus
1.01 for control and FMS subjects, respectively. This suggested a decrease in elastin production in patients with FMS. There were no differences in the average values of anti-alpha-elastin Abs in the FMS patients sera compared to the average value of the control samples, suggesting there was no differences in elastin destruction.
Conclusions: Variations in elastin metabolism were detected in sera of patients with FMS. This suggests an altered elastin metabolism in terms of reduced elastin production in patients with FMS. The relationship between elastinmetabolism and disease pathology is currently being explored. |
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Modificado el ( lunes, 23 de octubre de 2006 )
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