Dr. Ferran J. García

Jonathan Kerr ^1*, Beverley Burke ¹, Robert Petty ¹, John Gough ¹, David Fear ², Mattey David ³, John Axford ¹, Angus Dalgleish ¹ and David Nutt ⁴

¹ St George's University of London, United Kingdom
² Kings College London, United Kingdom
³ Sheffield Rheumatology Centre, United Kingdom
⁴ University of Bristol, United Kingdom

Chronic Fatigue Syndrome / myalgic encephalomyelitis (CFS/ME) is a multisystem disease, the pathogenesis of which remains undetermined. We have recently reported a study of gene expression which identified differential expression of 88 human genes in patients with CFS/ME. Clustering of QPCR data from CFS/ME patients revealed 7 distinct subtypes with distinct differences in SF-36 scores, clinical phenotypes and severity. In this study, for each CFS/ME subtype, we determined those genes whose expression differed significantly from that of normal blood donors, and then determined gene interactions, disease associations and molecular and cellular functions of those gene sets. Genomic analysis was then related to clinical data for each CFS/ME subtype. Genomic analysis revealed some common (neurological, cancer, immunological, inflammatory, haematological) and some distinct (metabolic, endocrine, dermatological, cardiovascular, connective tissue) disease associations among the subtypes. Subtypes 1, 2 and 7 were the most severe, and subtype 3 was the mildest. Clinical features of each subtype were as follows: subtype 1 (cognitive, musculoskeletal, sleep, anxiety / depression); subtype 2 (musculoskeletal, pain, anxiety / depression); subtype 3 (mild); subtype 4 (cognitive); subtype 5 (musculoskeletal, gastrointestinal); subtype 6 (postexertional); subtype 7 (pain, infectious, musculoskeletal, sleep, neurological, gastrointestinal, neurocognitive, anxiety / depression). It is particularly interesting that in these genomically derived subtypes, there were distinct clinical syndromes and that those which were most severe were also those with anxiety / depression, as would be expected in a disease with a biological basis.

Key Words: Gene expression, chronic fatigue syndrome, myalgic encephalomyelitis, subtype

Estudios recientes realizados en el Reino Unido el CFS encontró que existen siete subtipos de esta enfermedad. El informe de la JCP en línea dice:

 El Síndrome de Fatiga Crónica / Encefalomielitis miálgica (SFC / ME) es una enfermedad multisistémica, la patogénesis  sigue siendo indeterminada. Nos han informado recientemente de un estudio en la que la expresión de genes que se identifican la expresión diferencial de 88 genes humanos en pacientes con CFS / EM. LA QPCR agrupación de los datos de CFS / ME pacientes reveló 7 distintos subtipos con claras diferencias en las puntuaciones de SF-36, diferenciandose los fenotipos clínicos y la gravedad. En este estudio, para cada subtipo CFS / ME , que determinará los genes cuya expresión difiere significativamente de la de los donantes de sangre normal y, a continuación, determina la interacción de genes, la enfermedad y las asociaciones moleculares y celulares de las funciones de los conjuntos de genes. El Análisis genómico fue entonces relacionado con los datos clínicos de cada CFS / ME subtipo.

Los siete subtipos son:

• Subtipo 1 - cognitiva, musculoesquelético, trastornos del sueño, ansiedad / depresión
• Subtipo 2 - musculoesquelético, dolor, ansiedad / depresión
• Subtipo 3 - leve
• Subtipo 4 - cognitivo
• Subtipo 5 - musculoesquelético, gastrointestinal
• Subtipo 6 - postexertional
• Subtipo 7 - dolor, infecciosas, musculoesquelético, trastornos del sueño, neurológica, gastrointestinal, neurocognitivas, ansiedad / depresión

www. fibrofatiga-unidos.info

• tags, blog, expresion+genetica, sindrome+de+fatiga+cronica, encefalomielitis+mialgica, subtipos, gene+expression, chronic+fatigue+syndrome, myalgic+encephalomyelitis, subtype
• expresion+genetica, sindrome+de+fatiga+cronica, encefalomielitis+mialgica, subtipos, gene+expression, chronic+fatigue+syndrome, myalgic+encephalomyelitis, subtype